The Fc Receptor FcRn, Expressed in Intestinal Epithelial Cells, Binds

question 22

Essay

The Fc receptor FcRn, expressed in intestinal epithelial cells, binds to the Fc portion of IgG antibodies. Moreover, FcRn binds to IgG with high affinity at an acidic pH (<6.5) but not at physiological pH (pH 7.4). How is this biochemical feature of FcRn critical for its role in antigen presentations for gut immunity?

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Definitions:

Without Reserve

In an auction context, it refers to the selling of items without any minimum bid requirement, allowing the sale to the highest bidder regardless of the bid amount.

Auctioneer

A person authorized to conduct auctions, responsible for accepting bids and declaring goods sold.

Statute Of Frauds

A legal concept that requires certain types of contracts to be executed in writing and signed by the party to be charged, to prevent fraud and perjuries.

Oral Modification

An agreement to change the terms of a contract using spoken words rather than written documentation.