Mice Deficient in the Enzyme MMP7, That Cleaves Prepro- $\alpha$ -Defensin to the Active

question 15

Multiple Choice

Mice deficient in the enzyme MMP7, that cleaves prepro- $\alpha$ -defensin to the active $\alpha$ -defensin, show an increased susceptibility to the enteric pathogen, Salmonella typhimurium. The cell type in the gastrointestinal (GI) epithelium most likely to express the highest levels of MMP7 is:

• A) Goblet cells
• B) Paneth cells
• C) M cells
• D) GI-resident macrophages
• E) Intraepithelial lymphocytes

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