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Allergic Airway Inflammation Can Be Induced in Mice by Immunizing

question 22

Multiple Choice

Allergic airway inflammation can be induced in mice by immunizing them with an allergen that produces a TH2 effector response, and then challenging the immunized mice with an inhaled form of that allergen. In this disease model, the TH2 effector cells present in the lung respond to the inhaled allergen challenge by producing type 2 cytokines that recruit eosinophils and induce airway inflammation. In addition, a component of this TH2 response is antigen-independent, as shown by the effects of administering a neutralizing antibody along with the allergen challenge. This neutralizing antibody (anti-'X' IgG) has the effects shown in Figure Q14) . Allergic airway inflammation can be induced in mice by immunizing them with an allergen that produces a T<sub>H</sub>2 effector response, and then challenging the immunized mice with an inhaled form of that allergen. In this disease model, the T<sub>H</sub>2 effector cells present in the lung respond to the inhaled allergen challenge by producing type 2 cytokines that recruit eosinophils and induce airway inflammation. In addition, a component of this T<sub>H</sub>2 response is antigen-independent, as shown by the effects of administering a neutralizing antibody along with the allergen challenge. This neutralizing antibody (anti-'X' IgG)  has the effects shown in Figure Q14) .   antibody was shown to inhibit the response of the T<sub>H</sub>2 cells, and therefore is likely to be: A)  A neutralizing antibody to IL-12 B)  A neutralizing antibody to IL-4 C)  A neutralizing antibody to TSLP D)  A neutralizing antibody to STAT4 E)  A neutralizing antibody to IL-13 antibody was shown to inhibit the response of the TH2 cells, and therefore is likely to be:

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