The W/W^v Mouse Strain Is Heterozygous for Two Different Alleles

question 24

Multiple Choice

The W/W^v mouse strain is heterozygous for two different alleles of the gene encoding the growth factor receptor, c-kit, an important receptor expressed on hematopoietic progenitor cells in the bone marrow. The major defect in these mice is the absence of single lineage of hematopoietic cells. When these mice are challenged with larval Haemaphysalis longicornis ticks, they fail to become resistant to the ticks, in spite of generating high titers of anti-tick IgE antibodies. The cell type missing in the W/W^v mice is most likely:Natural Killer (NK) cells

• A) Eosinophils
• B) Tissue-resident dendritic cells
• C) Tissue-resident macrophages
• D) Tissue-resident mast cells

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