To Avoid the Potential for Activating Self-Reactive T Cells That

question 16

Essay

To avoid the potential for activating self-reactive T cells that might cause autoimmunity, naive T cell activation has stringent requirements for co-stimulatory signals in addition to the engagement of T-cell receptors with peptide:MHC complexes. Yet this requirement is abandoned once T cells have differentiated into effector cells. Name two effector T cell functions that would fail if effector T cells also required T-cell receptor signals plus co-stimulatory signals through CD28 to elicit their effector responses.

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Definitions:

Hypothalamus

A region of the brain that coordinates both the autonomic nervous system and the activity of the pituitary, controlling body temperature, thirst, hunger, and other homeostatic systems.

Cerebrum

The largest part of the brain, responsible for higher brain functions such as thought, action, and emotion.

Largest Part

The component or section of something that is the biggest in size or volume.

Human Brain

The central organ of the human nervous system, responsible for processing sensory information, regulating bodily functions, and enabling cognition, emotions, and memory.