Effector Caspases Are Activated Downstream of Both Extrinsic and Intrinsic

question 36

Multiple Choice

Effector caspases are activated downstream of both extrinsic and intrinsic pathways of apoptosis. Consequently, cells lacking one or more of these enzymes show defects in apoptosis. An alternative means of eliminating the activity of an effector caspase would be to:

• A) Generate a form of the pro-caspase with a mutation in the initiator caspase cleavage site
• B) Express a mutant form the caspase that lacked the pro-domain
• C) Express a constitutively active form of the initiator caspase
• D) Generate a knockout mutation that prevented expression of the Fas receptor
• E) Generate a mutation in the proteins required for autophagy

---

Definitions:

Salivate

The production of saliva in the mouth, often as a reflexive response to the sight, smell, or thought of food.

Classical Conditioning

The kind of learning in which an unconditioned response (such as salivating) that is naturally elicited by one stimulus (such as food) becomes elicited also by a new, conditioned stimulus (such as a bell).

Food Poisoning

A condition caused by consuming contaminated food or beverages with harmful bacteria, viruses, or other pathogens.

Nostalgia

A sentimental longing or wistful affection for the past, typically for a period or place with happy personal associations.