Following Their Activation, Naive CD4 T Cells Differentiate into One $\gamma$

question 37

Multiple Choice

Following their activation, naive CD4 T cells differentiate into one of several subsets of effector T cells. This developmental choice is determined by which specific cytokines the T cells are exposed to during their activation; in turn, the cytokines that are produced will reflect the nature of the infecting pathogen. In order for this system to be flexible enough to produce all five effector CD4 subsets (T_H1, T_H2, T_H17, T_FH, and iT_reg) :

• A) Each naive CD4 T cell must already express one of the lineage-specific transcription factors (i.e., T-bet, GATA-3, etc.).
• B) Each naive CD4 T cell must express all of the STAT proteins.
• C) Each naive CD4 T cell must express only a single STAT protein (i.e., STAT1 or STAT6 or STAT3, etc.).
• D) Each naive CD4 T cell must already express low levels of the subset specific cytokines (i.e., IFN\(\gamma\), IL-4, IL-17, etc.).
• E) Each naive CD4 T cell must express all of the lineage-specific transcription factors (i.e., T-bet, GATA-3, etc.).

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Definitions:

Territory

A defined geographical area under the jurisdiction of a political entity or state.

Soldier Deaths

The fatalities of military personnel during active duty, often examined in the context of specific conflicts or wars to analyze their impact and consequences.

Prisoner-of-war Camps

Facilities where prisoners of war (POWs) are held during conflict, intended to detain enemy combatants away from the battlefield while adhering to certain treatment standards set by international law.