In Different Mammalian Species, the Ratio of B Cells Expressing $\kappa$

question 22

Multiple Choice

In different mammalian species, the ratio of B cells expressing $\kappa$ versus $\lambda$ light chain-containing antibodies is about 65%:35%. In other species, such as mice, this ratio is vastly different, at 95%:5%. If a routine blood test performed on an individual revealed that their $\lambda$ -expressing versus $\lambda$ -expressing B cells were seen at a ratio of 95%:5%, this would likely indicate that the individual had:

• A) An increased number of functional V\(\kappa\) gene segments compared to the average human in the population
• B) A defect in allelic exclusion of antibody light chain genes
• C) A defect in isotypic exclusion of antibody light chains
• D) A lymphoproliferative disorder
• E) A genetic defect in one of their two \(\lambda\) light chain alleles

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