The Final Stages of T Cell Development Occur in the Thymic

question 19

Multiple Choice

The final stages of T cell development occur in the thymic medulla, after the developing cells become CD4 or CD8 single-positive. One important change that occurs during this final maturation is:

• A) The down-regulation of the pre-T-cell receptor \(\alpha\) (pre-T\(\alpha\)) chain protein
• B) The up-regulation of genes encoding effector cytokines and cytolytic effector proteins
• C) The increased susceptibility to T-cell receptor-induced apoptosis
• D) The loss of susceptibility to T-cell receptor-induced apoptosis
• E) The up-regulation of signaling proteins required for T cell activation

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