The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes$\alpha$

Question

Examlex · Accepted Answer

The Answer is The TCR

\beta

chain, but not the TCR

\alpha

chain is required for the pre-TCR to assemble at the CD4^-CD8^- (double-negative) stage of thymocyte development. The pre-TCR signal is critical for inducing double-negative thymocytes to differentiate into CD4⁺CD8⁺ double-positive thymocytes. This signal is also essential to induce multiple rounds of cell division as thymocytes progress from double-negative to double-positive. This proliferation leads to ~100-fold increase in thymocyte numbers. As a consequence, double-negative thymocytes lacking TCR

\beta

will fail to proliferate and will fail to differentiate into double-positive cells.

The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes $\alpha$

Definitions:

The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes α\alphaα

Definitions:

The Mouse Thymus Normally Contains About 1–2 X 108 Thymocytes $\alpha$