A Mutant Mouse Line (Mutant-X) Is Discovered That Is Defective

question 15

Multiple Choice

A mutant mouse line (Mutant-X) is discovered that is defective in generating IgG or IgA antibody responses to immunization with the inactivated influenza A virus vaccine. As a first step in determining the gene responsible for the immunodeficiency, T lymphocytes and B lymphocytes are separately isolated from wild-type or Mutant-X mice and mixtures of cells are transferred into Rag-deficient recipients, which are then immunized with the Influenza A vaccine as shown in Figure. Fourteen days later, serum from the immunized mice is collected, and tested for anti-influenza IgG and IgA antibody titers. The results are shown in Figure : mice is:

• A) NEMO
• B) CD40-ligand
• C) CD40
• D) AID
• E) TACI

Acknowledge the influence of cohort effects on research findings.

Comprehend the advantages and disadvantages of different research designs.

Grasp the concept of selective attrition and its implications on research.

Understand the procedure and utility of sequential research design.