An Important Transcription Factor Activated by Antigen Receptor Signaling in Lymphocytes

question 14

Multiple Choice

An important transcription factor activated by antigen receptor signaling in lymphocytes is an NF $\kappa$ B heterodimer of the two subunits, p50 and p65Rel. Defects in the I $\kappa$ B-kinase complex (NEMO) or mutations in I $\kappa$ B that prevent its phosphorylation interfere with NF $\kappa$ B activation and result in severe immunodeficiency diseases. This is due to the important function of:

• A) NEMO in targeting p50:p65Rel for ubiquitination and degradation
• B) NEMO in ubiquitinating I\(\kappa\)B causing its release from NF\(\kappa\)B
• C) I\(\kappa\)B in blocking the DNA binding activity of NF\(\kappa\)B
• D) I\(\kappa\)B as a chaperone to promote NF\(\kappa\)B nuclear localization
• E) NEMO in phosphorylating I\(\kappa\)B inducing its degradation, thereby releasing NF\(\kappa\)B

---

Definitions:

Status

The relative social, professional, or other standing of someone or something compared to others.

Tone

The attitude or emotional characteristics exhibited through word choice, writing style, or voice, affecting the overall feel conveyed by communication.

Instant Messaging

A form of real-time text-based communication between two or more people over the internet or a network, allowing for immediate receipt and response.

Text Messaging

The act of sending brief written messages via mobile devices or computer systems, a common form of digital communication.