Human Patients with Genetic Defects That Result in a Failure

question 15

Multiple Choice

Human patients with genetic defects that result in a failure to produce the calcium channel protein ORAI1, or the ER calcium sensor protein STIM1, have severe immunodeficiency diseases. An immunosuppressive drug that would most closely mimic these primary immunodeficiencies is:

• A) Rituximab, a drug that depletes B cells
• B) Cyclosporin A, a calcineurin inhibitor
• C) Rapamycin, an mTOR inhibitor
• D) Tysabri, an inhibitor of integrin binding
• E) Enbrel or Humira that inhibit TNF

---

Definitions:

Energized

Refers to a state in which an electrical component, circuit, or system is supplied with power and is operational.

Normally Open

Describes a switch or relay contact that is in a default open state, allowing current to flow only when the contact is actuated to close.

Normally Closed

A term referring to an electrical switch or circuit state where the contacts are closed (allowing current flow) when no actuating force is applied.

Electrical State

An electrical state refers to the condition of an electrical component or system, such as being charged, discharged, on, or off.