The TCR Signaling Module Leading to Transcription Factor Activation Is $\gamma$

question 7

Multiple Choice

The TCR signaling module leading to transcription factor activation is dependent on the enzyme phospholipase-C- $\gamma$ (PLC- $\gamma$ ) . The mechanism by which PLC- $\gamma$ activates multiple transcription factors is by:

• A) Generating two small second messengers that act on multiple target proteins in the T cell
• B) Directly cleaving inhibitory subunits of multiple transcription factors, thereby releasing the active transcription factors
• C) Generating two small second messengers that diffuse to the nucleus and activate transcription factors present there
• D) Generating two small second messengers that act as chaperones to promote nuclear localization of transcription factors
• E) Directly cleaving the lipid binding domain from membrane-tethered transcription factors, allowing them to migrate to the nucleus

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