A Cell Line Carrying a Mutation in a Single Gene

question 11

Essay

A cell line carrying a mutation in a single gene is found to express very low levels of MHC class I on its surface. When infected with influenza virus, these cells are not recognized nor are they killed by a CD8 T cell line specific for an influenza peptide bound to the MHC class I protein expressed by these cells. Incubation of the mutant cell line with a large excess of this peptide in the cell culture medium overnight leads to the results shown in
What is the most likely candidate for the gene that is defective in the mutant cell line?

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Definitions:

Gray Matter

The regions of the brain and spinal cord that are made up primarily of neuronal cell bodies and synapses, crucial for processing and integrating information.

White Matter

White matter consists of myelinated axons in the brain and spinal cord that transmit signals quickly across different brain regions, facilitating communication within the nervous system.

Thalamus

A part of the brain that serves as a relay station, transmitting information between different areas of the brain.

Hypothalamus

A region of the brain that coordinates many activities, including temperature regulation, thirst, hunger, and emotional activity.