The Addition and Subtraction of Nucleotides at the Junctions Between

question 30

Multiple Choice

The addition and subtraction of nucleotides at the junctions between V, D, and J gene segments creates antibody proteins with wide variations in the numbers of amino acids in their CDR3 regions. This variability in CDR3 length is important as:

• A) Overall variability in CDR3 sequence is needed to create a sufficiently diverse antibody repertoire.
• B) The CDR3 region is more important in binding antigen than the CDR1 and CDR2 regions are.
• C) Some light chains bind better to heavy chains with longer CDR3 region sequences.
• D) Longer CDR3 sequences generally create antibodies with higher affinity for the antigen.
• E) Some antibodies bind relatively flat surfaces and others bind deep clefts in the antigen.

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