Immunodeficiency Diseases Occur When Individuals Have Defects in Leukocyte Adhesion

question 25

Multiple Choice

Immunodeficiency diseases occur when individuals have defects in leukocyte adhesion to inflamed endothelial cells, thereby impeding the extravasation of phagocytes into infected tissues. When neutrophils from one class of these patients were isolated and tested using in vitro assays for neutrophil-endothelial cell interactions and extravasation, it was found that the neutrophils could slowly roll along the endothelial vessel wall but were unable to arrest and migrate across the endothelium. The most likely protein deficient in these neutrophils is:

• A) ICAM-1 or ICAM-2
• B) P-selectin
• C) E-selectin
• D) An integrin
• E) Sulfated sialyl-Lewis^X

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