Septic Shock Is a Serious, Often Fatal Response to an Infection

question 10

Multiple Choice

Septic shock is a serious, often fatal response to an infection in the bloodstream. This response can be elicited in mice by intravenous injection of bacterial LPS. However, it was found that one strain of mice, C3H/HeJ, is resistant to LPS-induced shock. This fact was used to clone the gene for TLR-4 based on positional cloning from C3H/HeJ mice. Another example of a strain of mice that is resistant to LPS-induced septic shock is:

• A) TNF-receptor-deficient mice
• B) TLR-2-deficient mice.
• C) LFA-1-deficient mice
• D) Neutrophil-deficient mice
• E) Complement receptor-deficient mice