Individuals with Defects in T Cell Development Have a Severe

question 42

Multiple Choice

Individuals with defects in T cell development have a severe immunodeficiency disease called SCID (severe combined immunodeficiency disease) . In these individuals, the absence of all T cells causes defects in both cell-mediated (T cell-based) and humoral (antibody-based) immune responses. The defect in antibody responses in SCID patients is due to:

• A) The important role of T cells in regulating B cell development in the bone marrow
• B) The inter-dependence of T cells and B cells for the normal development of secondary lymphoid organs.
• C) The absence of phagocytic cells needed for antibody-dependent pathogen clearance in SCID patients
• D) The poor survival of B cells in patients with defects in their T cells
• E) The important role of T follicular helper cells in generating protective antibody responses

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