You Measure the Initial Velocity of an Enzyme in the Absence

question 19

Essay

You measure the initial velocity of an enzyme in the absence and presence of two inhibitors. In each case, the inhibitor is at 10 µM. Shown in the table below is the primary data for all three cases. Construct a Lineweaver-Burk plot for each case. Calculate the KM and Vmax for each case, both graphically and mathematically. Determine the mechanism for each inhibitor and where each will interact on the enzyme.
Initial Velocity (µmol/ml min)
Enzyme Enzyme Enzyme
[S] mM Alone + Inhibitor 1 + Inhibitor 2
0.33 1.65 1.05 0.79
0.50 2.13 1.43 1.02
1.00 2.99 2.22 1.43
2.00 3.72 3.08 1.79
5.00 4.00 3.80 2.00

Understand the importance of psychoeducation for patients with bipolar disorder and their families to manage the condition post-discharge.

Recognize the signs that a patient with bipolar disorder may not be adhering to medication regimens and the steps to take in response.

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Understand the characteristics and manifestations of schizophrenia.

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Definitions:

Body Positions

The various postures or physical arrangements of the body and its parts, which can be important for health, in examinations, or surgical procedures.

Abduction of the Thumb

The movement of the thumb away from the hand's palm and the rest of the fingers, demonstrating thumb mobility and function.

Popliteal Space

The area behind the knee joint where the femur, tibia, and muscles related to knee movement are located.

Head Erect

An upright positioning of the head, typically used to improve breathing or digestion.