There Is a Spectrum of Syndromes in Humans Known as Xeroderma

question 16

Multiple Choice

There is a spectrum of syndromes in humans known as Xeroderma pigmentosum. The individuals that have XD most commonly have mutations in their nucleotide excision DNA repair mechanisms that make them particularly susceptible to environmental mutagens such as UV light. Individuals have to be careful with how much sunlight they are exposed to since they have an extremely elevated chance for developing skin cancer. There have been several cell lines that have been established from XD patients that can be studied in tissue culture. In an experiment several different cell lines of unknown origin were tested for their ability to undergo unscheduled DNA synthesis (UDS) , an assay for DNA repair. In this assay the amount of radioactive nucleotides that are incorporated into DNA after the cell sustains a mutagenic event are measured. The amount of radioactivity incorporated is measured by the number of counts per minute (CPM) . Below is a table from such an experiment. Which cell line is most likely from XD patient(s) ?

• A) A
• B) B
• C) C
• D) D

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Definitions:

Interpersonal Sensitivity

The ability to perceive and respond appropriately to the emotions and behaviors of others.

Rokeach's Categories

a classification system for values developed by Milton Rokeach, dividing them into terminal and instrumental values.

Social Traits

Characteristics or qualities that define how individuals interact socially with others, including personality attributes like extroversion or agreeableness.

Personal Conception Traits

Personal conception traits represent individuals’ major beliefs and personal orientation concerning a range of issues involving social and physical setting.