A Significant Polymorphic Inversion on Chromosome 17, the MAPT Inversion

question 1

Multiple Choice

A significant polymorphic inversion on chromosome 17, the MAPT inversion, is identified by marker SNPs that can now be used to screen large numbers in a population. The inverted region is large and extends for approximately 900 kb. The two haplotypes (one inverted and one not) are each associated with increased risk of a number of neurological conditions. How can the inverted region be used to find the most recent common ancestor of the inversion?

• A)by typing SNPs from humans and from other primates
• B)by assessing SNPs from a large number of human populations
• C)by looking for heterozygotes for the two kinds of chromosome 17
• D)by fertility studies on populations with each of the haplotypes
• E)by using a BAC clone library to identify the ends of the inversion

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Definitions:

Vagus Nerve

The tenth cranial nerve that controls the heart, lungs, and digestive tract, and plays a significant role in the parasympathetic nervous system.

Dorsal Respiratory Group

A cluster of neurons in the brainstem that plays a crucial role in initiating and maintaining the rhythmic cycle of breathing.

Respiratory Alkalosis

A condition characterized by a decrease in the carbon dioxide level in the blood, often due to rapid or deep breathing, leading to a pH imbalance where the blood becomes too alkaline.

Blood Ph

The measure of the acidity or alkalinity of the blood, typically maintained within a tight range around a neutral pH of 7.4.