A Researcher Is Studying a G Protein-Coupled Receptor in Eukaryotic

question 96

Multiple Choice

A researcher is studying a G protein-coupled receptor in eukaryotic cells. In one group of cells, he notices that even though a ligand can bind to its G protein-coupled receptor, nothing happens. Why could this happen?

• A)The G protein-coupled receptor might carry a mutation, so that it fails to undergo a conformational change upon the binding of its ligand.
• B)The G protein-coupled receptor might carry a mutation that affects the receptor's transmembrane portion.
• C)These cells might carry mutations in the downstream signaling pathway associated with this G protein-coupled receptor.
• D)All of these choices are correct.

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