Imagine That You Know Two SistersRose and Samboth

question 164

Multiple Choice

Imagine that you know two sistersRose and Samboth of whom smoke. Rose has a mutation in the gene for alpha-1 antitrypsin, whereas Sam does not. Which of the following statements is TRUE regarding these sisters?

• A)Because both sisters smoke, Rose and Sam will certainly develop emphysema; however, given her mutation, Rose will likely develop a much more serious form of the disease.
• B)Given that a mutation in alpha-1 antitrypsin serves a "protective" function against the development of emphysema, Rose will not develop this disease but Sam will.
• C)It is possible that neither Rose nor Sam will develop emphysema; however, the fact that both sisters smoke  added to the mutation that Rose carries  increases their chances of developing this disease.
• D)Rose is predisposed to develop emphysema, but if Sam does, this will be a random occurrence  environmental factors or lifestyle choices (such as smoking)have not been associated with emphysema.

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