An Experiment Reversed Rett Symptoms by Restoring MeCP2 Expression in Young

question 35

Essay

An experiment reversed Rett symptoms by restoring MeCP2 expression in young mice. Overexpression of MeCP2 causes significant neurological defects so the investigators used an interesting technique where they inserted a transcription stop site flanked by two loxP sites in between the transcription start site and the coding region.
A. What is the advantage of this technique?
B. The investigators then used tamoxifen-inducible CreER excision of the transcription stop site. What was the function of this procedure?

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Definitions:

Procedural Justice

The fairness and transparency of the processes that are used to make decisions and resolve disputes or grievances.

Distributive Justice

The perceived fairness of how rewards and resources are distributed among members of a group or society.

CRM

Stands for Customer Relationship Management; a technology for managing a company's relationships and interactions with current and potential customers.

Inventory Management

The process of ordering, storing, and using a company's inventory, including the management of raw materials, components, and finished products.