Which of the Following Issues Could Lead to Erroneous Estimates

question 1

Multiple Choice

Which of the following issues could lead to erroneous estimates of phylogenetic distance based on molecular clock analysis?

• A) Different lineages have very different basal mutation rates.
• B) DNA sequences that were subject to strong selection are used for the analysis.
• C) The basal rate of mutation varied over time within a lineage being analyzed.
• D) A very distant outgroup (with predominantly random base changes) is used to root the tree.
• E) All of the above

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