In an Experiment That Showed That CaMKII Was Involved in Synaptic

question 9

Multiple Choice

In an experiment that showed that CaMKII was involved in synaptic plasticity, one input was stimulated at high frequency (S1) , which induced LTP. LTP was not induced from a second input that was not stimulated at high frequency (S2) . Later in the same experiment, constitutively CaMKII was injected into the cell body of the postsynaptic neuron and both inputs were stimulated. Stimulation of which input resulted in LTP and why? Choose all that apply.

• A) Stimulation of S1 induced LTP because those synapses were already potentiated.
• B) Stimulation of S1 did not induce LTP because it was occluded by prior LTP.
• C) Stimulation of S2 induced LTP because of the presence of CaMKII that was paired with S2 stimulation.
• D) Stimulation of S2 did not induce LTP because it was not previously potentiated.

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