The Semaphorins Are Highly Conserved Axon Guidance Ligands with Critical

question 26

Essay

The semaphorins are highly conserved axon guidance ligands with critical roles in nervous system development in both mammals and insects. It was recently reported that Sema1A can also function as a transmembrane receptor in reverse signaling to mediate photoreceptor axon-axon attraction in the developing Drosophila visual system. What kind of experimental result would be used to support a role in reverse signaling in the visual system?

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Definitions:

Profit Margin

A financial metric indicating the percentage of revenue that remains as profit after accounting for costs and expenses.

Retention Ratio

The fraction of net profit not disbursed as dividends, instead held within the company.

EBIT

Earnings Before Interest and Taxes is a financial indicator that calculates a company's earnings by excluding interest and income tax expenses.

Interest Expense

The cost incurred by an entity for borrowing money, typically expressed as an annual rate applied to the borrowed principal.