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The Semaphorins Are Highly Conserved Axon Guidance Ligands with Critical

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The semaphorins are highly conserved axon guidance ligands with critical roles in nervous system development in both mammals and insects. It was recently reported that Sema1A can also function as a transmembrane receptor in reverse signaling to mediate photoreceptor axon-axon attraction in the developing Drosophila visual system. What kind of experimental result would be used to support a role in reverse signaling in the visual system?


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