Synaptic Transmission Can Be Potentiated by Release of Serotonin on the Presynaptic

question 1

Essay

Synaptic transmission can be potentiated by release of serotonin on the presynaptic terminal. In the experiments shown in Figure Q3-49, investigators used intracellular recording of the neuron and whole-cell patch recording of the potassium channels to understand how serotonin influences the action potential. Figure Q3-49
A. In experiment 1, what happened to the action potential when cAMP and serotonin (5-HT) were added to the extracellular space of the neuron (top trace) and cAMP was injected intracellularly into the neuron (bottom trace)?
B. In experiment 2, what happened to the potassium channel activity when serotonin was added to the outside of the cell and cAMP was added to the inside of the cell?
C. Summarize all the figures. How does serotonin increase the duration of the action potential (include the second messengers in your answer)?

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Definitions:

Correlation Coefficient

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Choices made by individuals or firms regarding the allocation of resources to different assets or projects with the expectation of earning a return.

Correlation

A numerical indicator that captures how much two variables move in tandem, showing both how strong their linkage is and in what direction it lies.