In T Cells,allelic Exclusion of the α-Chain Locus Is Relatively

question 42

Essay

In T cells,allelic exclusion of the α-chain locus is relatively ineffective,resulting in the production of some T cells with two T-cell receptors of differing antigen specificity on their cell surface.
A.Will both these receptors have to pass positive selection for the cell to survive? Explain your answer.
B.Will both receptors have to pass negative selection for the cell to survive? Explain your answer.
C.Is there a potential problem in having T cells with dual specificity surviving these selection processes and being exported to the periphery?

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Definitions:

Autonomic Nervous System

Part of the nervous system that controls involuntary body functions, such as heart rate, digestion, and respiration, divided into the sympathetic and parasympathetic nervous systems.

Parasympathetic Nervous System

Part of the autonomic nervous system that conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles.

Insulin

A hormone produced by the pancreas that regulates blood sugar levels by facilitating the uptake of glucose into tissues.

Pancreas

A glandular organ located in the abdomen that plays a crucial role in digestion and insulin production.