Hereditary Anemia Known as Sickle Cell Disease (SCD) Results from Inheritance

question 33

Essay

Hereditary anemia known as sickle cell disease (SCD) results from inheritance of a variant form of fi- globin protein (fiS), rather than the wild- type fi- globin protein (fiA). Which of the following did Linus Pauling find following gel electrophoresis of hemoglobin protein from individuals with the following three genotypes: fiAfiA, fiAfiS, or fiSfiS?
A) all three lanes had just one protein band with the same electrophoretic mobility
B) the lane containing the hemoglobin from the heterozygote (fiAfiS) individual had two protein bands with differing electrophoretic mobility
C) the lane containing the hemoglobin from the homozygous (fiAfiA) individual had two protein bands with differing electrophoretic mobility
D) the lane containing the hemoglobin from the homozygous (fiSfiS) individual with SCD had two protein bands
E) all three lanes had the same two protein bands with the same electrophoretic mobility

• A) all three lanes had just one protein band with the same electrophoretic mobility
• B) the lane containing the hemoglobin from the heterozygote (fiAfiS) individual had two protein bands with differing electrophoretic mobility
• C) the lane containing the hemoglobin from the homozygous (fiAfiA) individual had two protein bands with differing electrophoretic mobility
• D) the lane containing the hemoglobin from the homozygous (fiSfiS) individual with SCD had two protein bands
• E) all three lanes had the same two protein bands with the same electrophoretic mobility

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