What Is the Pathophysiologic Process Responsible for the Autoimmune Disorder

question 21

Multiple Choice

What is the pathophysiologic process responsible for the autoimmune disorder of hemolytic-uremic syndrome (HUS) ?

• A)Immunoglobulin A (IgA) coats erythrocytes that are destroyed by the spleen, and remnants are excreted through the kidneys.
• B)Verotoxin from Escherichia coli is absorbed from the intestines and damages erythrocytes and endothelial cells.
• C)Endotoxins from E. coli block the erythropoietin produced by the kidneys, which reduces the number of erythrocytes produced by the bone marrow.
• D)Failure of the nephron to filter urea increases the blood urea nitrogen, which binds to erythrocytes that are subsequently destroyed by the spleen.

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