A Mutation in the Cdc28 Gene in the Budding Yeast

question 19

Multiple Choice

A mutation in the cdc28 gene in the budding yeast Saccharomyces cerevisiae causes cell-cycle arrest, giving rise to unbudded cells that look like "dumbbells." Treatment of wild-type cells with nocodazole, a drug that destabilizes some cytoskeletal polymers, leads to a similar phenotype. Based only on these observations, which statement is true regarding cdc28?

• A) cdc28 codes for a master regulatory kinase that phosphorylates other proteins.
• B) Nocodazole binds to the protein coded by the cdc28 gene.
• C) The product of the cdc28 gene is responsible for resistance to nocodazole.
• D) The product of the cdc28 gene is involved in cell cycle regulation.
• E) The product of cdc28 destabilizes the same cytoskeletal polymers that nocodazole also destabilizes.

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