Consider the Two Feed-Forward Loops Below Containing Three Transcription Regulators

question 8

Short Answer

Consider the two feed-forward loops below containing three transcription regulators A, B, and C, where A receives the input signal and C generates the output. In the so-called coherent loop (left), A activates C both directly and indirectly, whereas in an incoherent loop (right), A activates C via one route and inactivates it via the other. Answer the following question(s) based on these network motifs.

-Would you expect a coherent (C) or an incoherent (I) loop to generate the following response pattern? In this example, A is stimulated by the input, and the transcription of C is measured as the output. Write down C or I as your answer.

---

Definitions:

Ambivalence

Mixed feelings or contradictory attitudes towards an object, person, or action, making decision-making difficult.

Change

The process of becoming different, often implying an evolution or transformation in characteristics, conditions, or behaviors.

Problem

A situation, question, or issue that presents difficulty, uncertainty, or challenge, which requires a solution or response.