How Does a Eukaryotic Cell Deal with the Superhelical Tension

question 3

Multiple Choice

How does a eukaryotic cell deal with the superhelical tension in its genomic DNA resulting from the activity of RNA polymerases?

• A) DNA gyrase introduces negative supercoils, keeping the DNA under constant tension.
• B) The RNA polymerases are allowed to rotate freely around their templates during transcription, leading to the relaxation of the tension.
• C) DNA topoisomerases rapidly remove the superhelical tension caused by transcription.
• D) The nucleosomes adjust the tension by binding to positively supercoiled regions behind a moving RNA polymerase.
• E) All of the above.

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