If Two Genomic Polymorphic Sites Were Randomly and Independently Associated

question 48

Short Answer

If two genomic polymorphic sites were randomly and independently associated with each other, one would expect the frequency of observing a combination of their allelic forms in an individual to be equal to the multiplication product of the probability of the alleles occurring separately. In many cases, however, this is not true. The degree of deviation from random association can be quantified and summarized in diagrams such as the one below. In this diagram, eight SNPs in a genomic region are shown and their pairwise deviation from random association is color-coded by different shades of red, such that the darkest red shade indicates the furthest deviation from random association. In contrast, those pairs that associate randomly are colored white. For example, SNPs A and F seem to associate randomly as indicated by the corresponding box marked with black borders. From this diagram, two haplotype blocks can be readily detected. What subset of the shown SNPs is not part of any of the two blocks? Write down the letter(s) as your answer, in alphabetical order, e.g. CEH.

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Definitions:

Spending Variance

The difference between the actual amount spent and the budgeted amount for a particular period or item.

Actual Level

The real, measured level of production, performance, or activity, as opposed to planned or theoretical levels.

Spending Variance

The difference between the actual amount spent and the budgeted amount for a particular category or period, indicating over or under spending.

Planning Budget

A financial plan that estimates the revenue and expenses for a specific period, often used for setting performance expectations.