Consider a Transcription Regulatory Protein That Has Both a Nuclear

question 5

Multiple Choice

Consider a transcription regulatory protein that has both a nuclear localization and a nuclear export signal and is normally found both in the nucleus and in the cytosol at comparable concentrations. This protein has a high-affinity binding partner in the nucleus. Upon activation of a certain signaling pathway, the binding protein is ubiquitylated and degraded. As a result of this, ...

• A) the transcription regulatory protein accumulates in the nucleus.
• B) the transcription regulatory protein accumulates in the cytosol.
• C) the distribution of the transcription regulatory protein does not change, but the expression of its target genes may be altered.
• D) the distribution of the transcription regulatory protein does not change, and the expression of its target genes is not necessarily changed as a result of the degradation event.

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