A 2-Year-Old Boy Is Being Evaluated at the Office for Failure

question 89

Multiple Choice

A 2-year-old boy is being evaluated at the office for failure to thrive and developmental delay.  Medical history is significant for recurrent ear infections since 6 months of age.  Physical examination shows corneal clouding, hepatosplenomegaly, and restricted joint mobility.  Further evaluation shows deficient phosphorylation of mannose residues on certain glycoproteins in the Golgi apparatus.  In unaffected patients, these proteins are normally transported to which of the following cellular locations?

• A)Endoplasmic reticulum
• B)Extracellular space
• C)Lysosome
• D)Mitochondria
• E)Plasma membrane

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Definitions:

Friendships

Relationships based on mutual affection, respect, and trust, typically offering companionship and support between individuals.

Evolutionary Pressure

Forces or factors that influence the chances of survival and reproductive success of organisms, leading to natural selection and evolution.

Successful Pregnancy

A pregnancy that results in the birth of a living infant who is carried to full term without significant complications.

Replacement Level

The fertility rate at which a population exactly replaces itself from one generation to the next, without migration.