A 68-Year-Old Man Comes to the Office Due to an Enlarging

question 4

Multiple Choice

A 68-year-old man comes to the office due to an enlarging mole on his right forearm.  The patient is a retired farmer and received a significant amount of sun exposure over the course of his life.  On examination, he has a black-brown macular lesion on the dorsum of his right forearm measuring approximately 1 cm in diameter with an irregular border.  Excisional biopsy is performed and histopathology reveals malignant melanoma.  Immunohistochemical analysis indicates that the malignant cells have decreased integrin expression.  These cells are most likely to exhibit poor adhesion to which of the following components of the extracellular matrix?

• A)Actin
• B)Fibronectin
• C)Hyaluronic acid
• D)Keratan sulfate
• E)Keratin

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Definitions:

Subcontrary

In logic, propositions that cannot both be false, but can both be true, especially within the square of opposition.

Subalternate

In classical logic, the term for propositions that are related in such a way that the truth of one implies the truth of the other.

Existential Import

The implication that some individuals fitting the criteria exist when making a particular proposition.

Existential Import

The implied existence of at least one instance of the subject in categorical propositions, affecting the truth of the proposition.