A 64-Year-Old Man Is Evaluated for Persistent Fever and Weakness

question 162

Multiple Choice

A 64-year-old man is evaluated for persistent fever and weakness.  He has a history of aortic valve replacement for aortic stenosis.  Physical examination reveals a new cardiac murmur with scattered petechiae and splinter hemorrhages seen on his extremities.  Echocardiogram shows a vegetation involving one of the aortic valve leaflets, and blood cultures grow enterococci.  As part of the patient's treatment, 240 mg of intravenous gentamicin is started.  The pharmacy calculates that, in this patient, gentamicin has a volume of distribution of 30 L, a half-life of 4 hours, and demonstrates first-order and one-compartment kinetics.  Which of the following is the most likely serum drug concentration just before the next dose 8 hours later?

• A)0)5 mg/L
• B)1 mg/L
• C)1)5 mg/L
• D)2 mg/L
• E)3 mg/L

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Definitions:

Persuasion

The action or process of influencing someone's beliefs, attitudes, or actions through argument or appeal.

Audience's Attitudes

The feelings, beliefs, and behavior tendencies directed towards a person, object, or idea by the audience.

Deception

The act of misleading or tricking someone into believing something that is not true.

Falsification

The act of disproving a hypothesis or theory by presenting evidence that contradicts it.