For Some Rare Autosomal Dominant Diseases, It Is Possible That

question 1

Essay

For some rare autosomal dominant diseases, it is possible that the dominant homozygote has never been seen. One reason is that the fetus with this genotype may die early in development and be spontaneously aborted. In fact, roughly 25% of all women will have a pregnancy end in spontaneous abortion at some point during their lifetimes. Consider a situation in which
Q/Q dies as an early fetus; Q/q lives to reproduce but is unaffected; q/q lives and is unaffected. What genotypes are possible among live-born children of the mating Q/q × Q/q? (Hint: Construct a 2-by-2 table to reflect the genotypes of the parents.)

---

Definitions:

Democratic Party

One of the two major contemporary political parties in the United States, historically associated with progressive policies and social liberalism.

Monroe Doctrine

A principle of US foreign policy, articulated by President James Monroe in 1823, which opposed European colonialism in the Americas and declared any intervention in the Western Hemisphere as a threat to US security.

Manifest Destiny

A 19th-century doctrine or belief that the expansion of the United States throughout the American continents was both justified and inevitable.