What Is the Mechanism of Action of the Sipuleucel-T Prostate

question 4

Multiple Choice

What is the mechanism of action of the sipuleucel-T prostate cancer vaccine?

• A) Dendritic cells are incubated with a fusion protein containing prostate specific antigen (PSA) and GM-CSF.
• B) A plasmid that codes for an antibody that expresses prostate specific antigen (PSA), and dendritic cells present PSA to T cells.
• C) A single B cell clone that is tumor specific is grown in the lab and infused into the patient to produce large amounts of tumor specific antibody.
• D) Patient tumor cells are exposed to a viral vector containing a gene for prostate specific antigen (PSA), and then the tumor cells are infused into the patient to stimulate an immune response.

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Definitions:

Resistance Change

The opposition or pushback encountered when attempting to implement changes, often due to comfort with the status quo or fear of the unknown.

Underlying Restraining

Fundamental barriers or obstacles that prevent progress or the achievement of an objective.

Change Agent

An individual or group that drives and facilitates organizational change, often by influencing and encouraging others to adopt new processes, behaviors, or approaches.

Unfreezing

The initial phase in the change process where existing patterns or behaviors are dismantled to prepare for the introduction of new methods or ways of functioning.