The Oxygen Dissociation Curve of Hemoglobin Is Sigmoidal, and This

question 8

Multiple Choice

The oxygen dissociation curve of hemoglobin is sigmoidal, and this raises the efficiency of oxygen delivery considerably.The reason for hemoglobin's sigmoidal oxygen dissociation curve is:

• A)The steric control of oxygen access to the heme iron by the distal histidine.
• B)The difference in oxygen affinity between the heme groups of the α chains and those of the β chains.
• C)A conformational change in the protein that raises the oxygen-binding affinities of the other heme groups when one of them becomes oxygenated.
• D)The effect of 2,3-BG, which binds only to oxygenated but not deoxygenated hemoglobin.
• E)The hydrophobicity of the heme-binding pocket, which forces oxygen to diffuse through a hydrophobic medium in order to reach the heme iron.

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