Scientists Studying the Causes of a Type of Progressive Hearing

question 48

Multiple Choice

Scientists studying the causes of a type of progressive hearing loss known as otosclerosis want to identify the genetic contribution to the disorder. By which of the following are they most likely to find a causative gene or genes?

• A)a genome-wide association study with a large number of SNPs, using pooled DNA samples
• B)genome-wide linkage analysis studies of families whose members have otosclerosis
• C)a candidate gene case-control association study with genes known to be involved in ear development
• D)comparison of gene expression among otosclerosis patients
• E)allelic heterogeneity studies for a gene expected to be involved

---

Definitions:

Evidence-Based Management

Evidence-Based Management involves making organizational decisions based on the best available scientific evidence, rather than on personal preference or tradition.

Multiple Sources

Involves collecting or receiving information from more than one origin to provide a broader perspective or verify accuracy.

Analytics

The systematic computational analysis of data or statistics, used to inform decision-making or enhance performance.

General Electric

A multinational conglomerate corporation specializing in sectors such as energy, healthcare, digital industry, and aviation.