A Mouse Model for Multiple Sclerosis Is Induced by Immunizing $\beta$

question 26

Multiple Choice

A mouse model for multiple sclerosis is induced by immunizing mice with murine central nervous system proteins mixed with Complete Freund's adjuvant. This adjuvant contains components that stimulate both TLR2 and TLR4. The adjuvant is essential to the development of autoimmunity because:

• A) It induces copious amounts of type I interferons.
• B) It prevents the differentiation of CD4 T_H2 effector cells.
• C) It activates dendritic cells to up-regulate co-stimulatory molecules.
• D) It promotes tissue damage that mimics a central nervous system viral infection.
• E) It prevents the production of TGF-\(\beta\) by astrocytes in the central nervous system.