Polymorphisms in the IL-2R $\alpha$ Chain Gene Are Associated with Multiple Autoimmune Diseases, Including Type

question 22

Multiple Choice

Polymorphisms in the IL-2R $\alpha$ chain gene are associated with multiple autoimmune diseases, including type 1 diabetes, vitiligo, multiple sclerosis, Crohn's disease, autoimmune thyroiditis, and juvenile arthritis. One hypothesis for this striking list of disease associations with polymorphisms in the IL-2R $\alpha$ chain gene is that these alterations affect the function of FoxP3+ regulatory CD4 T cells. If this was the case, one would expect that disease-associated alleles of the IL-2R $\alpha$ chain gene would:

• A) Result in enhanced IL-2 production by FoxP3+ regulatory CD4 T cells
• B) Result in enhanced proliferation of FoxP3+ regulatory CD4 T cells
• C) Lead to reduced IL-2 production by FoxP3+ regulatory CD4 T cells
• D) Lead to enhanced development of FoxP3+ regulatory CD4 T cells in the thymus
• E) Result in reduced responsiveness of FoxP3+ regulatory CD4 T cells to IL-2

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