Nearly All Immune Deficiency Diseases That Result in Impaired T_H17

question 24

Essay

Nearly all immune deficiency diseases that result in impaired T_H17 and ILC3 function lead to chronic mucocutaneous candidiasis (CMC), usually accompanied by increased susceptibility to pyogenic bacterial infections. However, a subset of these patients also show increased susceptibility to intracellular bacterial infections, such as those caused by Mycobacteria species. What is the explanation for why some, but not all, of these patients have increased susceptibility to intracellular bacteria and which patients fall into this category?

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Definitions:

Horizontal Communication

The exchange of information, messages, or communication across the same levels of an organization or among peers.

Downward Communication

The flow of information from higher levels of an organizational hierarchy to lower levels, typically involving directives, updates, and feedback.

Pent-up Emotions

Refers to feelings that a person has suppressed or not expressed over a period of time.

Pent-up Emotions

Emotions that have been suppressed or not expressed, often leading to increased stress or emotional outbursts.