Inflammatory Bowel Disease (Colitis) Is a CD4 T-Cell Mediated Disease $\gamma$

question 17

Multiple Choice

Inflammatory bowel disease (colitis) is a CD4 T-cell mediated disease that can be transferred to naive mice by administration of effector CD4 T cells that home to the gastrointestinal tract and induce inflammation. Simultaneous administration of neutralizing antibodies to IL-12p40 can prevent the disease, as can neutralizing antibodies to IL-23p19. Disease symptoms can be exacerbated by administration of IL-23, but not of IL-12. These data strongly suggest that:

• A) Both T_H1 and T_H17 effector cells contribute to disease.
• B) T_H1 cells producing INF-\(\gamma\) are the major causes of disease.
• C) IL-12p35 is a critical component of disease induction.
• D) The inducible IL-12R\(\beta\) subunit is essential for disease induction.
• E) Neutralizing antibodies to IL-17 would prevent disease.

---

Definitions:

Obsessions

Uncontrollable, persistent thoughts, images, ideas, or impulses that an individual feels intrude on his or her consciousness and that cause significant anxiety or distress.

Compulsions

Repetitive behaviors or mental acts that an individual feels he or she must perform.

Avoidant Personality Disorder

A disorder characterized by a long-standing pattern of extreme shyness, feelings of inadequacy, and sensitivity to rejection, leading to social inhibition and avoidance of social interactions.

Genetics

The study of genes, genetic variation, and heredity in living organisms; explaining how traits and characteristics are passed from one generation to the next.