A T Cell Line Growing in Culture Is Subjected to a Chemical

question 31

Multiple Choice

A T cell line growing in culture is subjected to a chemical mutagen, and individual mutant lines are derived from this population. The individual mutant cell lines are each screened for their ability to proliferate in response to stimulation with antibodies to the T-cell receptor plus CD28 (anti-CD3 + anti-CD28) . In addition, the cells are treated with varying doses of added IL-2, and three days later, T cell proliferation is measured by ³H-thymidine incorporation (cpm) . The data for one mutant line and the wild-type control are shown in Figure Q16) .
Figure Q16) The gene that is defective in this mutant T cell line most likely encodes:

• A) The CD3 epsilon subunit of the T-cell receptor complex
• B) The co-stimulatory molecule CD28
• C) CD25, also known as the IL-2 receptor \(\alpha\) chain
• D) The IL-2 receptor \(\beta\) chain
• E) The cytokine IL-2

Comprehend the significance of specific performance and the conditions under which it applies.

Identify the conditions under which breaches of warranty occur.

Understand the remedies available to sellers when buyers breach contracts.

Learn the procedures and justifications for resale by sellers in breached contracts.

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Definitions:

Leader-Member Exchange Theory

A concept that centers on the relationship between leaders and their followers, emphasizing the effect of these dynamics on work outcomes.

Relationship

A connection, association, or involvement between two or more parties, individuals, or entities.

LMX

Leader-Member Exchange theory, which focuses on the two-way (dyadic) relationships between leaders and followers.

OCB

Stands for "Organizational Citizenship Behavior," referring to the voluntary contributions of employees beyond their formal job requirements.